Download Noninferiority Testing in Clinical Trials Free Books - Dlebooks.net

Download Noninferiority Testing in Clinical Trials Free Books

CRC Press

English - 212 pages - ISBN-10: 1466561491 - ISBN-13: 9781466561496

4/5 by 49 votes


Take Your NI Trial to the Next Level Reflecting the vast research on noninferiority (NI) designs from the past 15 years, Noninferiority Testing in Clinical Trials: Issues and Challenges explains how to choose the NI margin as a small fraction of the therapeutic effect of the active control in a clinical trial. Requiring no prior knowledge of NI testing, the book is easily accessible to both statisticians and nonstatisticians involved in drug development. With over 20 years of experience in this area, the author introduces the basic elements of the NI trials one at a time in a logical order. He discusses issues with estimating the effect size based on historical placebo control trials of the active control. The book covers fundamental concepts related to NI trials, such as assay sensitivity, constancy assumption, discounting, and preservation. It also describes patient populations, three-arm trials, and the equivalence of three or more groups.

Reviews

64x64

Demotte Craig

Could not let the book down Sure not a literary master piece, but as one of the reviewers stated, it will keep you turning the pages.

Michael Ivan

Nice It has a nice story about how to always let go the past and fall in love.

Michael Craig

Incredible This book took over my life and I could not put it down.

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